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acy 957  (MedChemExpress)


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    Structured Review

    MedChemExpress acy 957
    Organotypic retinal explants were derived from wild-type (WT) and Rho I255d/+ mice at post-natal (P) day 12 and cultured <t>with</t> <t>ACY-957</t> (ACY; A ) from P14 to P20. The non-treated (NT) WT situation was used as reference (dashed lines in B – D ). A The TUNEL assay (red) labeled dying cells in outer nuclear layer (ONL) and inner nuclear layer (INL) of both WT and Rho I255d/+ mutant retina. DAPI (grey) was used as nuclear counterstain. Quantification of TUNEL-positive cells in ONL ( B ) and INL ( C ). Note the strong rise in TUNEL positive cells at 10 µM ACY concentration. D In Rho I255d/+ mutant retina, the ONL row count indicated a significant increase at 10 µM ACY, when compared to NT mutant. Data represent mean and SD, and were obtained from 5 to 16 independent retinal explant cultures; statistical analysis: Two-way ANOVA test with two-stage linear step-up procedure of Benjamini, Krieger, and Yekutieli; * p ≤ 0.05, ** p ≤ 0.01, **** p ≤ 0.0001.
    Acy 957, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 92/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/acy+957/pmc12848085-21-0-11?v=MedChemExpress
    Average 92 stars, based on 3 article reviews
    acy 957 - by Bioz Stars, 2026-08
    92/100 stars

    Images

    1) Product Images from "Differential effects of HDAC inhibitors in the Rho I255d mouse model for autosomal dominant retinitis pigmentosa"

    Article Title: Differential effects of HDAC inhibitors in the Rho I255d mouse model for autosomal dominant retinitis pigmentosa

    Journal: Cell Death Discovery

    doi: 10.1038/s41420-025-02908-9

    Organotypic retinal explants were derived from wild-type (WT) and Rho I255d/+ mice at post-natal (P) day 12 and cultured with ACY-957 (ACY; A ) from P14 to P20. The non-treated (NT) WT situation was used as reference (dashed lines in B – D ). A The TUNEL assay (red) labeled dying cells in outer nuclear layer (ONL) and inner nuclear layer (INL) of both WT and Rho I255d/+ mutant retina. DAPI (grey) was used as nuclear counterstain. Quantification of TUNEL-positive cells in ONL ( B ) and INL ( C ). Note the strong rise in TUNEL positive cells at 10 µM ACY concentration. D In Rho I255d/+ mutant retina, the ONL row count indicated a significant increase at 10 µM ACY, when compared to NT mutant. Data represent mean and SD, and were obtained from 5 to 16 independent retinal explant cultures; statistical analysis: Two-way ANOVA test with two-stage linear step-up procedure of Benjamini, Krieger, and Yekutieli; * p ≤ 0.05, ** p ≤ 0.01, **** p ≤ 0.0001.
    Figure Legend Snippet: Organotypic retinal explants were derived from wild-type (WT) and Rho I255d/+ mice at post-natal (P) day 12 and cultured with ACY-957 (ACY; A ) from P14 to P20. The non-treated (NT) WT situation was used as reference (dashed lines in B – D ). A The TUNEL assay (red) labeled dying cells in outer nuclear layer (ONL) and inner nuclear layer (INL) of both WT and Rho I255d/+ mutant retina. DAPI (grey) was used as nuclear counterstain. Quantification of TUNEL-positive cells in ONL ( B ) and INL ( C ). Note the strong rise in TUNEL positive cells at 10 µM ACY concentration. D In Rho I255d/+ mutant retina, the ONL row count indicated a significant increase at 10 µM ACY, when compared to NT mutant. Data represent mean and SD, and were obtained from 5 to 16 independent retinal explant cultures; statistical analysis: Two-way ANOVA test with two-stage linear step-up procedure of Benjamini, Krieger, and Yekutieli; * p ≤ 0.05, ** p ≤ 0.01, **** p ≤ 0.0001.

    Techniques Used: Derivative Assay, Cell Culture, TUNEL Assay, Labeling, Mutagenesis, Concentration Assay

    Dose-response curves (log scale) for SAHA (magenta), MPT0G211 (green), and ACY-957 (blue). A Effects on cell death as evidenced by the TUNEL assay. B Photoreceptor survival as assessed by outer nuclear layer (ONL) row counts. C Numbers of cone photoreceptors per 100 µM of retinal circumference. D Quantification of HDAC activity positive cells in the ONL. E Quantification of ONL cells showing caspase-3 activation. F Quantification of ONL cells displaying calpain-2 activation. Data obtained from 4 to 16 independent retinal explant cultures; data points indicate mean and SD; statistical analysis: Two-way ANOVA test with two-stage linear step-up procedure of Benjamini, Krieger, and Yekutieli; * p ≤ 0.05; ** p ≤ 0.01; *** p ≤ 0.001, **** p ≤ 0.0001.
    Figure Legend Snippet: Dose-response curves (log scale) for SAHA (magenta), MPT0G211 (green), and ACY-957 (blue). A Effects on cell death as evidenced by the TUNEL assay. B Photoreceptor survival as assessed by outer nuclear layer (ONL) row counts. C Numbers of cone photoreceptors per 100 µM of retinal circumference. D Quantification of HDAC activity positive cells in the ONL. E Quantification of ONL cells showing caspase-3 activation. F Quantification of ONL cells displaying calpain-2 activation. Data obtained from 4 to 16 independent retinal explant cultures; data points indicate mean and SD; statistical analysis: Two-way ANOVA test with two-stage linear step-up procedure of Benjamini, Krieger, and Yekutieli; * p ≤ 0.05; ** p ≤ 0.01; *** p ≤ 0.001, **** p ≤ 0.0001.

    Techniques Used: TUNEL Assay, Activity Assay, Activation Assay



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    Image Search Results


    Organotypic retinal explants were derived from wild-type (WT) and Rho I255d/+ mice at post-natal (P) day 12 and cultured with ACY-957 (ACY; A ) from P14 to P20. The non-treated (NT) WT situation was used as reference (dashed lines in B – D ). A The TUNEL assay (red) labeled dying cells in outer nuclear layer (ONL) and inner nuclear layer (INL) of both WT and Rho I255d/+ mutant retina. DAPI (grey) was used as nuclear counterstain. Quantification of TUNEL-positive cells in ONL ( B ) and INL ( C ). Note the strong rise in TUNEL positive cells at 10 µM ACY concentration. D In Rho I255d/+ mutant retina, the ONL row count indicated a significant increase at 10 µM ACY, when compared to NT mutant. Data represent mean and SD, and were obtained from 5 to 16 independent retinal explant cultures; statistical analysis: Two-way ANOVA test with two-stage linear step-up procedure of Benjamini, Krieger, and Yekutieli; * p ≤ 0.05, ** p ≤ 0.01, **** p ≤ 0.0001.

    Journal: Cell Death Discovery

    Article Title: Differential effects of HDAC inhibitors in the Rho I255d mouse model for autosomal dominant retinitis pigmentosa

    doi: 10.1038/s41420-025-02908-9

    Figure Lengend Snippet: Organotypic retinal explants were derived from wild-type (WT) and Rho I255d/+ mice at post-natal (P) day 12 and cultured with ACY-957 (ACY; A ) from P14 to P20. The non-treated (NT) WT situation was used as reference (dashed lines in B – D ). A The TUNEL assay (red) labeled dying cells in outer nuclear layer (ONL) and inner nuclear layer (INL) of both WT and Rho I255d/+ mutant retina. DAPI (grey) was used as nuclear counterstain. Quantification of TUNEL-positive cells in ONL ( B ) and INL ( C ). Note the strong rise in TUNEL positive cells at 10 µM ACY concentration. D In Rho I255d/+ mutant retina, the ONL row count indicated a significant increase at 10 µM ACY, when compared to NT mutant. Data represent mean and SD, and were obtained from 5 to 16 independent retinal explant cultures; statistical analysis: Two-way ANOVA test with two-stage linear step-up procedure of Benjamini, Krieger, and Yekutieli; * p ≤ 0.05, ** p ≤ 0.01, **** p ≤ 0.0001.

    Article Snippet: ACY-957 (ACY, A) , , HDAC-1, , HDAC-1: 7 nM , MedChemExpress , , [ ] .

    Techniques: Derivative Assay, Cell Culture, TUNEL Assay, Labeling, Mutagenesis, Concentration Assay

    Dose-response curves (log scale) for SAHA (magenta), MPT0G211 (green), and ACY-957 (blue). A Effects on cell death as evidenced by the TUNEL assay. B Photoreceptor survival as assessed by outer nuclear layer (ONL) row counts. C Numbers of cone photoreceptors per 100 µM of retinal circumference. D Quantification of HDAC activity positive cells in the ONL. E Quantification of ONL cells showing caspase-3 activation. F Quantification of ONL cells displaying calpain-2 activation. Data obtained from 4 to 16 independent retinal explant cultures; data points indicate mean and SD; statistical analysis: Two-way ANOVA test with two-stage linear step-up procedure of Benjamini, Krieger, and Yekutieli; * p ≤ 0.05; ** p ≤ 0.01; *** p ≤ 0.001, **** p ≤ 0.0001.

    Journal: Cell Death Discovery

    Article Title: Differential effects of HDAC inhibitors in the Rho I255d mouse model for autosomal dominant retinitis pigmentosa

    doi: 10.1038/s41420-025-02908-9

    Figure Lengend Snippet: Dose-response curves (log scale) for SAHA (magenta), MPT0G211 (green), and ACY-957 (blue). A Effects on cell death as evidenced by the TUNEL assay. B Photoreceptor survival as assessed by outer nuclear layer (ONL) row counts. C Numbers of cone photoreceptors per 100 µM of retinal circumference. D Quantification of HDAC activity positive cells in the ONL. E Quantification of ONL cells showing caspase-3 activation. F Quantification of ONL cells displaying calpain-2 activation. Data obtained from 4 to 16 independent retinal explant cultures; data points indicate mean and SD; statistical analysis: Two-way ANOVA test with two-stage linear step-up procedure of Benjamini, Krieger, and Yekutieli; * p ≤ 0.05; ** p ≤ 0.01; *** p ≤ 0.001, **** p ≤ 0.0001.

    Article Snippet: ACY-957 (ACY, A) , , HDAC-1, , HDAC-1: 7 nM , MedChemExpress , , [ ] .

    Techniques: TUNEL Assay, Activity Assay, Activation Assay